Principal Scientist, Internal Medicine

at Pfizer
Published May 7, 2022
Location Cambridge, MA
Category Default  
Job Type Full-time  Intern  



The Internal Medicine Research Unit (IMRU) is seeking a highly talented and motivated scientist to apply Metabolomics and Lipidomics expertise towards the development of therapeutics which improve human health. As a key member of the Metabolism and Mass Spectrometry laboratory in the Internal Medicine Research Unit, this individual will contribute to the identification and validation of new targets, and the development of novel compounds for the treatment of metabolic diseases including cachexia, HFpEF, hyperinsulinemia and other diseases where dysmetabolic states play a key pathophysiological role. Through the application of LCMS, GCMS and other analytical techniques, the individual will collaboratively design, execute and interpret metabolomic, lipidomic and flux experiments to answer biological questions including determining pathological mechanism of disease, drug mechanism of action, identifying PD markers to drive decision-making, and aiding in the translation of biomarkers to clinical labs. As a scientific and technical expert, this individual is expected to contribute to and lead collaborations with academic labs, pushing the boundaries of the field to maintain cutting edge technology and methodology. The candidate will be involved in drug discovery research projects from early target identification to drug development, and will thrive in a multidisciplinary team environment requiring excellent oral and written communication skills.

The successful candidate must demonstrate:

  • Advanced knowledge of the principles, concepts, and practices in separation science and mass spectrometry as applied to Metabolomics, Lipidomics and Flux.
  • Ability to work collaboratively with subject matter experts contributing to experimental design and data interpretation.
  • Innovation and self-motivation, capable of working independently as well as in the team setting.


  • Develop and apply U-HPLC / MS (Thermo Orbitrap and Bruker TTP) to acquire high quality metabolomics and lipidomics data. Process data through case appropriate bioinformatics tools to transform data into interpretable results, make conclusions, and suggest next steps.
  • Identify target engagement and pharmacodynamic biomarkers to drive decision making, and clinical translation.
  • Conduct and supervise biomarker assays in support of portfolio programs, including performing metabolite extractions, conducting LCMS, quantifying analytes and interpreting results.
  • Propose appropriate stable isotope tracer techniques to answer specific biological questions.
  • Collaborate with Quantitative Systems Pharmacology to quantify fluxes.
  • Bring new technologies and bioinformatics tools into the lab. Work collaboratively to fully integrate and automate new workflows.
  • Maintain and troubleshoot LCMS and GCMS instruments.
  • Communicate results effectively to a cross-functional team
  • Supervise 2 lab-based colleagues
  • Strive to publish scientific and methodological results in high quality journals


  • PhD in Chemistry or a related field, with 5+ years relevant post-PhD experience in Metabolomics, Lipidomics or Flux Modeling
  • Deep understanding of lipid chromatography and mass spectrometry, including HRAM (Orbitrap) and triple quadrupole instruments. GCMS is a plus.
  • Excellent written and oral communication skills
  • Working knowledge of cellular metabolism


Lifting, sitting, bending, standing, walking


Eligible for Relocation Package

Eligible for Employee Referral Bonus

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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